From the #1 Doctor Recommended brand for pain relief and fever reduction, TYLENOL® 8 HR Arthritis Pain Caplets provide fast-acting, temporary relief of minor arthritis, osteoarthritis and joint pain. Each caplet contains 650 mg of acetaminophen and features a bi-layer design with two layers of effective pain relief – the first dissolves fast and the second lasts up to 8 hours to ease minor arthritis pain.